Importance of Interkingdom Interactions Among Oral Microbiome Towards Caries Development – A Review

The human microbiome plays a crucial role in health and disease conditions. These microbiomes constitute structured, coordinated microbial network throughout the body. oral cavity harbors one of extensively diverse bacteria system. Although many studies emphasize bacteriome its interaction with host system, very little attention is given to candidate phyla radiation (CPR), fungal components, interkingdom microecology even advanced techniques. interactions among caries causing microbes trigger pathogenesis bacterial diseases cause ecological shifts affect Studying complex relations host, especially CPR fungi, would give holistic view etiology. This review provides evidence on that establishes community could help predict future systemic diseases.